Hypothyroidism is defined as the failure of the Thyroid Gland to produce sufficient Thyroid hormone to meet the metabolic demands of the body. Untreated Hypothyroidism can contribute to Hypertension, Dyslipidemia, Infertility, Cognitive impairment, and neuromuscular dysfunction. Data derived from the National Health and Nutrition Examination Survey (NHANES III) suggest that about one in 300 persons in the United States has Hypothyroidism there is a 4 – 5 % prevalence of Hypothyroidism in the developed world. The prevalence of Hypothyroidism in urban India is 10.95 %. A major portion of Hypothyroidism (approximately 3.47 %) remains undetected. Various treatment protocols are applied in this disease with partial success. In a present clinical study, 30 patients with clinically proven Hypothyroidism were treated with Kanchanar Gutika to evaluate its efficacy. The Ingredients Of Kanchanar Gutika are Bhibhitak (Terminalia Bellerica), Haritaki (Terminalia Chebula ) ,Amalaki (Emblica Officinalis ), Kanchanara (Bauhinia Variegate ) , Maricha (Piper Nigrum) , Shunthi ( Zinziber Officinalis) , Pippali (Piper Longum) , Guggul (Commiphora Mukul ) etc. Ayurvediya nidanadi parameters and modern symptoms of Hypothyroidism were used as subjective parameters & investigation was used as objective parameters to assess the efficacy of the drug. Analysis was done and results were calculated statistically using the paired‘t’ test. Results obtained are encouraging and indicate the efficacy of Kanchanar Gutika in the management of Hypothyroidism, exploring many aspects of this clinical entity.