INTRODUCTION: The vesiculobullous lesions of the skin are a group of heterogeneous diseases characterized by the formation of vesicles/blister and are associated with variable clinical manifestations and have multiple causes. The immunobullous disease are mainly a consequence of pathogenic autoantibodies which target those antigens which mainly function to maintain either cell to cell adhesion within the epidermis or adhesion of stratified squamous epithelium to dermis or mesenchyme