Background: The compliance with standards in health services is non-negotiable as it is fundamental in improving KSA current poor health outcomes, restoring patient and staff confidence in the public healthcare system, achieving widespread sustainable development and providing basic quality healthcare in KSA. Despite the growing interest in understanding the a etiology of chronic diseases, limited studies exist on medication noncompliance, especially, among perturbing and rural dwellers in KSA. Barriers to medication adherence in patients can have significant differences that made researchers confute to conclude that medication adherence is required to be more explored, and then, beneficial interventions develop to decrease these barriers. Some of the main barriers to patient compliance with pharmacological therapy The barriers to medication adherence included four concepts, namely, lifestyle challenges, patient incompatibility, forgetting of medicine use, and no expert advice. These concepts are always present in the disease process and reduce the patients' efforts to achieve normal living and adhere to the medication. Medication non-adherence when patients don’t take their medications as prescribed is unfortunately fairly common, especially among patients with chronic disease.Most non-adherence is intentional patients make a rational decision not to take their medicine based on their knowledge, experience and beliefs There are many reasons for noncompliance with in patients for medication .