Fenugreek is commonly used herb in Ayurveda. Fenugreek seeds (F.S) actually deadens the sense of sweet tastes and also the bitterness of bitter substances. Present study was carried out to determine the cardiotonic activity by using infusion of F.S with different dilutions & compared with cardiotonic activity of digoxin‐the life saving cardiotonic. The activity was tested by using isolated frog heart assembly. The present preliminary studies confirm the b etter cardiotonic activity of Fenugreek seeds extract than digoxin. Further studies can confirm the reduced toxicity & this will be the advantage of F.S over digitalis. Thus, in future it will be interesting to isolate the active chemical constituents which are responsible for the c ardiotonic activity.