In clinical practice, nonspecific antidiarrheals (allopathic and ayurvedic) are commonly used by clinicians along with routine treatment to hasten the recovery and to give psychological reassurance. Although they are used extensively in practice, studies comparing their efficacy are few. This prospective observational study was carried out at two private clinics run by pediatricians to compare the efficacy, safety, and tolerability of DIAREX, an ayurvedic antidiarrheal formulation versus loperamide in the treatment of acute diarrhea.