Aim: This randomized controlled clinical trial aimed to clinically evaluate the efficacy of coronally advanced flap (CAF) and platelet-rich fibrin membrane (PRF) with or without demineralized freeze-dried bone allograft (DFDBA) in the management of isolated gingival recession defects. Methods: A total of 20 bilateral Miller’s Class I/II recession defects were randomly treated with CAF+PRF (control group; n=10) and CAF+PRF+DFDBA (test group; n=10). Outcomes such as gingival index, plaque index, probing depth, recession depth, width of keratinized gingiva, and clinical attachment level were recorded at baseline and 6 months post-surgery. Root coverage percentage was obtained at 6 months postoperatively. Results: Clinical parameters in both control and test groups at baseline and 6 months showed statistically significant (p<0.05) improvement in probing depth, recession depth, clinical attachment level, and increase in the width of keratinized gingiva. Clinical parameters between the CAF+PRF group and CAF+PRF+DFDBA group were compared at 6 months post-surgery and there was no statistically significant difference. (p>0.05) The percentage of root coverage at 6 months post-surgery was statistically significant (p<0.05) in both control and test groups. At 6 months post-surgery, although the root coverage was found to be better with the addition of DFDBA, there was no statistically significant difference between both groups. (p>0.05) Conclusion: Both the control and test group sites healed uneventfully. However, the above findings are suggestive of no additional benefit of using DFDBA. The histological evaluation regarding the nature of periodontal healing at the end of 6 months would have been the most appropriate method to evaluate the intergroup comparison outcomes in this study