Abstract Background: Androgenetic Alopecia is a hereditary non-scarring androgen-dependent progressive thinning of the scalp. Objective: To compare between minoxidil intradermal injection by derma pen versus dutasteride intradermal injection by derma pen and derma pen alone in the treatment of male pattern baldness. Patients and Methods: This study was conducted on 45 Egyptian males with androgenetic alopecia collected from the Al-Zahraa outpatient clinic from the period 2018 to 2019. Approval from the Research Ethics Committee of Faculty of Medicine for Girls, AL-Azhar University was obtained. All of the participants gave informed consent to participate in the study. Results: In the current study, other adverse effects, such as impotence, ejaculation disorder, or gynecomastia, were not reported. No serious adverse effects were reported. No local side effects in the current study may due to appropriate sterilization of the device and the use of only fully licensed and tested agents together with micro-needling are important. Conclusion: Our study proved that dutasteride, minoxidil injection, and derma pen injection are an effective, safe, and trustworthy treatment for male androgenetic alopecia patients. Treatment of male androgenetic alopecia at any age and any BASP grade of androgenetic alopecia is possible and effective. Therefore, the study concluded that starting treatment at a younger age and earlier stage of androgenetic alopecia give better results