Aim: To compare staplers vs simple interrupted vs sub-cuticular method of skin closure of surgical wounds. Material and method:The present randomized prospective study was conducted in the Department of Surgery at Rohilkhand Medical College and Hospital, Bareilly from January 2020 to October 2021 among 150 subjects who underwent surgical procedures. Equal number of patients was allotted to 3 groups by random envelope allocation method i.e. Group A(Stapled skin closure), Group B(Interrupted skin closure) and Group C(Sub cuticular skin closure). Following the completion of closure, an antiseptic medicated cream was applied followed with a protective dressing for the first 24–72 h. Subcutaneous Drains were placed in selective cases according to infection and were kept till the drain content was minimal. All patients were given IV antibiotics for 5–7 days postoperatively. The closures were removed after an interval of 10–14 days, first removing the alternate sutures and then the remaining sutures after few days and pain on removal was recorded using VAS.