Abstract: Background :. Impacted mandibular third molar removal is one of most commonly practiced minor oral surgical procedure performed by oral surgeons. It causes injury to the highly vascularized area, causing complications like pain, swelling and trismus. Bromelain, a botanical enzyme leads to significantly decrease the sequalae after removal of impacted third molar. Aim:. Comparison of efficacy of bromelain and aceclofenac to reduce post-operative complications after removal of third molar. Material and methods :Patients having impacted third molar selected for study. The sample population is 72 and will be divided in 2 groups, each consisting 36 patients. Group 1 will be prescribed with Bromelain capsules 250 mg TDS for 5 days and Group 2 will be prescribed Tab. Aceclofenac BD for 5 days. The sequalae of mandibular third molar surgery include pain, swelling and trismus is measured in two groups and data collected. Expected Results : Student’s unpaired t-test will be analyse the data from the on 1 st ,3 rdand 7 thday postoperatively . A comparison of both drugs will be achieved by unpaired ttest. The variables include pain, swelling and trismus. When all the parameters will be compared till six postoperatively, the bromelain shows significant results in reducing postop complications like pain, edema and trismus in removal of impacted third molar. Conclusion : Bromelain said to have greater efficacy than Aceclofenac for reducing sequlae like pain, swelling and trismus after impacted third molar surgery.