Introduction: Patients with advanced liver disease receiving liver transplantation often become hypotensive during surgery. Factors that promote hypotension include profound systemic vasodilation, negative inotropy and vasodilation associated with anesthetics, potential for excessive bleeding during hepatectomy, and post reperfusion syndrome (PRS) after reperfusion of the liver graft. Contrary to common belief and practice, detailed analysis of intraoperative blood pressure showed that well-maintained average blood pressure does not always correlate with improved outcome. Materials and Methods: A prospective comparative study was conducted at Department of Liver transplant Anaesthesia and Intensive Care, AIG hospitals, Gachibowli, Hyderabad from April 2020 to April 2023 (3 years) in 500 patients). 500 patients (250-Femoral arterial BP monitoring, 250-Radial arterial BP monitoring). Femoral arterial BP monitoring, Radial arterial BP monitoring was done during dissection, anhepatic and reperfusion phages. Requirement of inotropes during femoral arterial BP monitoring, Radial arterial BP monitoring were measured simultaneously. Results: Femoral Arterial BP monitoring was done in 250 patients during orthotopic living donor liver transplantation, Radial Arterial BP monitoring was done in 250 patients during orthotopic living donor liver transplantation. Male patients were 410 (82.05%), females were 90 (17.95%). Male predominance was seen in our study