This study was conducted to study about the rationality of the different fixed dose drug combinations (FDC) prescribed by Doctors. A retrospective study was conducted after collecting prescription from patients attending private clinics and Government hospitals. The rationality of FDC formulations was studied on the basis of FDCs recommended by WHO in its list of essential drugs. Audit of the prescriptions reveals that 75% of the prescriptions contained FDC formulations However, FDCs in accordance with recommended WHO list of FDCs were only 11%. The most common prescribed were antimicrobials and analgesics which constitute nearly 30.5% of the total FDCs prescribed. In 52% of the prescriptions, the prescribed FDCs contained ingredients which were not essential for the desired therapeutic effect. 80% of the FDCs prescribed did not conform to the recommended WHO list. However, the use of cetain FDCs was highly justified and rational.