Cancer is spreading like an epidemic affecting all the age groups. In adolescents, it can create a sense of isolation from their friends and family members. It can cause significant psychological distress among them associated with anxiety, stress and can even lead to depression. The objective of the study was to find out coping, perceived social support and hope among adolescent cancer patients and also to determine the relationship between these variables. A descriptive, correlational research design was adopted. 100 adolescents attending the OPD of three hospitals in Bhubaneswar were selected conveniently. Modified cancer coping questionnaire, the multidimensional scale of perceived social support and Herth hope scale was used to assess coping, perceived social support and hope respectively. Mean level of coping was 97.33±12.28. Perceived support from family members was higher than friends. There was a significant positive relationship between coping, perceived social support and hope among adolescents.