Introductory information/relevance (Background): Widespread prevalence of toxic hepatitis from chemical factors, the growth of chronic forms of the disease, leading to a decrease in working capacity of the working population, determine the multidimensionality of the problem and the relevance of the development of new methods of prevention and treatment using a set of herbal medicines. Objective: Experimental study of the influence of the pesticide parargyte on the functional state of hepatocytes and correction of metabolic processes with the use of decoction from the complex of plant preparations. Methods: Experimental studies were carried out on 146 white male rats weighing 190-210. The mechanism of biological action of hepatotropic factors was studied in acute and chronic experiments and correction of metabolic processes with the addition of plant antioxidants. Results (Findings): Experimental studies revealed that under the influence of the pesticide propargit was observed a disturbance of carbohydrate energy metabolism in the liver in all study periods. Application of a complex of plant preparations to poisoned animals normalized the carbohydrate energy metabolism and improved the functional state of the liver. Conclusion: Application of the complex of herbal medicines - nettle leaves, black currant fruits, rose hips, mountain ash fruits, green tea with pesticide poisoning has a hepatoprotective effect on liver metabolism.