Online ISSN: 2515-8260

Correlation of D-dimer levels with severity of dengue fever

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1Dr Jilla Naganna, 2Dr Gadiga Srikanth Goud, 3Dr Sneha, 4Dr Vasanth Kumar Suram

Abstract

Introduction: Thrombocytopenia and bleeding are common complications of dengue fever. Platelet count is a poor predictor of bleeding manifestations. A surrogate marker of bleeding can be D-Dimer assay which is often used to describe coagulation activity in a patient. This project aims to study the correlation of D-dimer level with coagulation parameters so that d-dimer assay can be considered as an important predictor and prognostic marker for development of hemorrhage or shock in dengue. Methodology: This was a cross sectional study done on dengue patients attending Gandhi hospital from 2019 to 2021. Patients were grouped in to 2 groups – group1 having no bleeding manifestations and group 2 having bleeding manifestations. D-dimer levels in both groups were compared with platelet count, aPTT, PT and INR. Means of both groups were compared using student’s unpaired t-test. p value of <0.05 was taken as significant. Correlation of d-dimer with thrombocytopenia and coagulation parameters was done using Pearson’s correlation

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