Background: Gallbladder disease is the commonest surgical problem and cholecystectomy is the most frequently performed operation. In spite of modern standards of pre-operative preparation and refinements in anesthetic and operative techniques, post-operative wound infections occur in quite a number of patients. With introduction of newer and costlier antibiotics for preventing post-operative wound infection1 . Methods: 139 patients with gallstone disease who undergone cholecystectomy in All india institute of medical sciences Patna. Data related to the objectives of the study were collected. Adult patients undergoing elective or emergency cholecystectomy were taken for the study. clinical examination and underwent various investigations including complete blood counts, liver function tests, renal function tests, ECG, X-ray and ultrasonography. Results: Most of the patients undergoing cholecystectomy were in the mean age group of 45- 54 years, with ages ranging between 15 to 77 years, and this is consistent with the observations made by Ferzli (1991)5. In our series, females (105) outnumbered the males (34). This indicates a higher incidence of the gallbladder stone in females as compared to males in the respective age groups6 .