Introduction: Aim: To evaluate the efficacy of self-structured coping module on the intensityof stress and coping ability within parents of preterm neonates admitted in selected hospitals of Odisha. Methods and material: A quasi-experimental study with pre-test and post-test control group design was carried out among 110 patientswhich were chosen by purposive sampling method. selfstructured parental stressor scale was applied to measure the level of parental stress among parents of preterm neonates. Modified coping health inventory was used to measure the parental coping strategy.the self-structured coping module was given to the study group. The post-test was conducted after 4 days. Result: The findings showed a value of 12.58 at p<0.05 level suggests that a self-structured coping module had a significant effect on the level of stress. t value of -20.084 at p< 0.05 level proposed that self-structured coping module had a considerable effect on improving coping strategy among parents of preterm neonates. Conclusion:The study concluded that a self-structured coping module is one of the contemporary therapies that are proved effective in reducing stress levels and improving coping ability among parents of preterm neonates.