Background:Accumulating studies have suggested that all ages people are susceptible to SARS-CoV-2 infection, which can result in severe and even fatal respiratory diseases. The present study is to evaluate the determinants of disease severity and death among young adults affected with COVID-19. Materials and Methods: This prospective study includes a cohort of 100 adult patients who presented to Victoria Hospital and Bowring and Lady Curzon Hospital attached to BMCRI, Bangalore and were diagnosed with Covid-19 between May 2021 to August 2021. Patients were diagnosed with Covid-19 when symptomatic for Covid-like symptoms and had a positive SARS-CoV-2 nasopharyngeal PCR