Abstract: The total amount of biologically active compounds - antioxidants, flavonoids, and vitamin C in different trees for example in Morusnigra L., Prunuspersica L., Serasus Vulgaris L., and Juglansregia L. leaves were found at different seasons. The results showed that the highest concentration of antioxidants in spring was found in walnuts and peaches than in the summer season. The number of walnut leaves was about 9.105 ± 0.05 mg/g, and in peach, leaves were about 9.082 ± 0.075 mg/g. In spring, the content of flavonoids in the leaves of grapes was high and amounted to 4721 ± 0.521 mg/g, in the summer their number was 3825 ± 0.255 mg/g, and in the fall there was a decrease in flavanoids to 1.460 ± 0.2253 mg/g. In the spring, in the stalks of grapes, flavonoids were 4.386 ± 0.046 mg/g, in cocoons 0.348 ± 0.023 mg/g.