The aim is to determine the integration between risk factors for the occurrence of depressive disorders and to develop an algorithm for assessing the degree of risk of post-infarction depression. This study included patients with MI admitted to a cardiological hospital (754 patients). To achieve this goal, patients with depressive disorders were selected from this cohort. Of the total number of patients, 31% (233) had symptoms of depression (main group). For comparative analysis, the control group included patients with MI without depressive disorders - 108 observation units. Statistical data processing was carried out in two stages: 1) preparation for statistical analysis; 2) the actual statistical analysis. To distinguish persons with different risk probabilities, the range is divided into three intervals: the smallest, average, and largest. Accordingly, the prediction groups are also distinguished according to the ranges: a group with a relatively favorable prognosis, a group of attention, a group of an unfavorable prognosis. The use of the prognostic table allows us to identify the degree of probability of the risk of developing DS among patients with MI. It will enable cardiologists as well as primary care physicians to identify the symptoms of DS at earlier stages of myocardial infarction. The development of criteria for assessing the risk of developing DS among patients with MI will allow timely detection of DS and adjust the treatment of patients with MI, taking into account DS. Thus, in the first hours after myocardial infarction after the patient is admitted to the clinic, it is necessary to carry out measures to assess the risk of depressive disorders with the determination of anxiety states, low mood and predisposing factors by a cardiologist, possibly with the appointment of tranquilizers with a pronounced anxiolytic effect. In the first week after myocardial infarction, in the presence of depressive symptoms in patients, it is necessary to consult a psychiatrist for the clinical diagnosis of depression and to determine its severity using the Mothgomery-Asberg scale. If depressive disorders are detected, it is necessary to determine the clinical characteristics (the leading component of the depressive triad, the type of affect, the presence of suicidal components, the severity) of depression and the appointment of appropriate antidepressant treatment, with the agreement of a cardiologist and a psychiatrist at the same time