Abstract: Diagnostic and treatment approaches aimed at identifying risk factors for the development and formation of recurrent dental per implants has been developed. Complex therapy of destructive processes in periodontitis was carried out in 74 patients with chronic generalized periodontitis of combined cardiovascular system and with partial secondary adentia before dental implantation. It was found out that the key risk factors of early inflammatory complications and dental mucositis development in the delayed period of implant functioning are the pathogenic flora increase in the peri-implant zone.