The rising prevalence of many diseases is a growing concern in worldwide. Antioxidants are substances that prevent oxidation of other compounds or neutralize free radicals. Spices and herbs are rich sources of antioxidants. They have been used in many areas like food and beverages to improve its flavor, aroma and color. Due to their excellent antioxidant activity, spices and herbs have also been used to treat some diseases. This review focuses on the association between antioxidants and therapeutic approaches that may be the key to their use as potential remedy to treat various diseases. The antioxidant properties of some species and its importance in medicine to treat several diseases and its chemical compositions were discussed and summarized. The antioxidants play a major role in the area of medicine in next generation. This might be a novel approach in the field of medicine to treat various diseases and disorders