HIV increases susceptibility to various types of infections, cancer, other diseases and can cause death. Sleman is the highest case of HIV in Province DIY. Sleman Health Office records HIV/AIDS cases increased in 2015(1.038 cases) to 2016 (1.220 cases). WHO defines quality of life as an individual’s perception of their position in the cultural context and value system Research Objectives : to find out the correlation between the duration of diagnosed HIV with the quality of life (QOL) of people living with HIV/AIDS (PLWHA) at Yayasan Victory Plus in 2019. Research Methods: This study used a retrospective cohort design. Consecutive sampling used tofound 38 samples of respondents with HIV/AIDS at Yayasan Victory Plus. The research instrument was a questionnaire. Data analyzed by chi square and logistic regression. Results: The results of the Chi-Square test showed that duration of diagnosed HIV (p = 0.017) has significantly correlation with the quality of life PLWHA. Age, education, occupation, duration of ARV therapy, and income did not have a significant correlation. The results of multivariate analysis showed that the duration of diagnosed was the most influential factor of quality of life PLWHA (p-value = 0.002, RR = 96.404). Conclusion: Diagnosed duration of HIV has a significant correlation with the quality of life PLWHA. Respondents who were diagnosed for longer had the chance to have a poor quality of life. 8.3% PLWHA who are diagnosed longer and ≥ 30 years old have a poor quality of life.