INTRODUCTION.: Chronic Obstructive Pulmonary Diseases (COPD) is a common preventable and treatable diseases. An Exacerbation of COPD is an acute worsening of respiratory symptoms beyond normal day-to-day variations. It’s not only presents with respiratory symptoms, but also with many extra pulmonary manifestations. Disturbance in serum electrolytes is one of an extra pulmonary manifestation. The objective of the study was to find out these serum electrolytes (sodium, potassium) abnormalities in Acute Exacerbation of Chronic Obstructive Pulmonary Diseases (AE COPD) patients.