Basella alba has hypo-glycemic activity. The present study evaluated the benefits of the natural antioxidant, Basella alba, in treating the effect of age-related oxidative stress. Male Wistarrats of 3- , 12- and 18-months of age received a daily oral supplement of Basella alba for a period of 3 months. At the end of this period, markers of oxidative stress were assessed in the erythrocytes. Basella alba lowered oxidative stress in erthrocytes. These results demonstrated the antioxidant activity of Basella alba probably confers the capacity to reduce oxidative stress in erythrocytes of aging rats. They also suggest a critical role for Basellain reducing blood glucose level and better haemoglobin content.