Abstract The AAR for colon cancer in women is 3.9/100,000. Men rank rectal cancer ninth and colon cancer eighth. Rectal cancer does not appear on the list, but colon cancer does. 2. Thiruvananthapuram, Banglore, and Mumbai were the cities with the highest CRC AAR for men in 2013. (3.9). (3.7). The highest female CRC AAR (5.3) is found in Nagaland, followed by Aizwal (4.5) 2. In 224 colorectal cancers, the Cancer Genome Atlas Network discovered similar genetic alterations in colon and rectal tissues regardless of anatomic location and origin. Tumors of the colon and rectum were grouped by researchers. This study thoroughly examined the information connecting NSAID use to anastomotic leak. Animal experimental models and human clinical data were utilised to support this research. Clinical effects of NSAIDs on patients are measured using laboratory data. These inadequate instruments can measure the immeasurable. The second most frequent large intestine cancer is rectal carcinoma. CRC is a problem for world health. It is the second most common cancer in women (571000 cases, 9.5%) and the third most common cancer in men (663000 cases, 10.1% of all cancer cases). 1. 60% of incidents occur in developed countries. The fourth most common cause of death and the cause of 8% of all cancer deaths is CRC. Males in India had colon and rectal cancer AARs of 4.5 and 4.1 per 100,000, respectively.