Uterine fibroid is a non-malignant tumour that are most commonly presented in women of reproductive growth age. Clinical symptoms that frequently manifested are heavy menstrual bleeding, recurrent pregnancy loss and subfertility. The causes of development of fibroid is not well understood but strong evidence supported that one of the causes is the combination of action of progesterone and estrogen. Administration of Monosodium glutamate (MSG) for long period of times has reported to induced uterine fibroid in female Wistar rats. Research reviewed includes clinical manifestation, statistics and treatment with types of substance abuse and meeting future challenges in Malaysia. Therefore, medicinal plants extract has been used as an alternative approached to treat uterine fibroid compare to surgical procedures. This review is an effort to update the medicinal plants extract used worldwide to treat uterine fibroid.