Background: In India, breast cancer is the major reason for death in regenerative-age women. Early identification assumes a significant aspect in reducing breast cancer-related morbidity and mortality. BSE is the most practical strategies for early recognition of breast cancer. Nurses play a unique role in creating awareness among the people regarding BSE, and early detection of Breast Cancer, as they usually have the closest and effective connection with them. So, proper knowledge & practice regarding the BSE technique is required for nursing students to save themselves as well as the society from Breast cancer. Methodology: The research study was preexperimental. Total sixty no. of students of B. Sc Nursing 2nd year were chosen as samples from SUM Nursing College, Bhubaneswar by using a purposive sampling technique. Socio-demographic data Performa, self-constructed knowledge questionnaires were used to achieve the purpose of this study. A structured teaching program was organized for 1hour 30minutes to enhance the knowledge of students regarding BSE. Results: The findings of the study revealed that the Structured teaching program enhanced the knowledge level of students regarding BSE (before intervention 11.583.56 & after intervention 18.052.57). The results revealed that there was a significant difference in knowledge scores after intervention as the calculated t-test value & p-value were 11.38 & 0.00001 respectively, (t59=2.0009 p-value ≤0.05). Conclusion: The conclusion drawn from the study was: BSE related knowledge of students of B.Sc Nursing was upgraded after this structured teaching program.