Background: Wet cupping is a traditional and alternative treatment that is still used to reduce patients’ pain in several Eastern and European countries. It has been proven effective and has an essential role in reducing pain and as a treatment for many diseases in past studies. Nowadays, there is a growing interest in the field of complementary and alternative medicine (CAM). This discipline includes a diverse set of approaches used for prevention and treatment of many diseases. Several benefits of CAM have been proven, and it may be considered an effective modality for disease prevention, treatment of non-communicable diseases and for improving the quality of life of individuals with chronic medical conditions.2 Many patients who may not be satisfied with the outcomes of modern medicine, particularly those with chronic diseases, may be satisfied with the outcomes of CAM. Pain is the most common reason for seeking therapeutic alternatives of conventional medicine. Cupping, wet or dry, is an ancient treatment, which was broadly utilized in several communities, and it was recommended by the Islamic society.