Background: The women during the Pre and post-menopause period experience a wide range of menopausal symptoms that jeopardize their lifestyle and they have to cope physically, psychologically, socially, and spiritually. Aim: The study is planned to find out the effect of yoga therapy on quality of life among perimenopausal women in two selected community Khurda district, Odisha. Methods and material: A quasi-experimental study with a pre-test post-test control group design was adopted for this study. Through a self-structured checklist on symptoms of perimenopause, about120 perimenopausal women aged between 40-50 years were identified having perimenopausal symptoms. The yoga training was provided to the study group. Post-test was conducted after 30 days. Result: The mean age of women was 46 years. The mean score in the psychosocial domain was highest (57.8) among all the domains. The symptom of depression scored the highest (30%) among all the tests. In the control group, the post-test mean score of QOL was 84.93±3.96 and 85.76±2.67 experimental group was 74.52±13.31 and 59.9±10.5 which was statistically significant. In the experimental group, the pre-test and post-test mean scores of QOL were 74.52±13.17 and 59.9±10.5 which was statistically extremely significant. The mean post-test quality of life among perimenopausal women in the control and experimental group was 85.76±3 and 59.9±10.5 respectively and found statistically significant (p <0.0001). The quality of life was found significantly associated with the parity of women. Conclusion: The current study evident that, yoga therapy is effective in improving the quality of life among perimenopausal women. The physical and psychosocial symptoms reduced among women to a significant level after receiving yoga and women were physically and psychologically stronger than before. Hence yoga is a recommended measure in the reduction of symptoms in perimenopausal women.