Research objective: to compare the effectiveness of different drug abortion schemes in late pregnancy in women with a uterine scar in the Republic of Buryatia. Material and research methods. The study involved 47 women with a scar on the uterus who were shown to terminate a pregnancy for medical reasons in the second trimester. The patients were divided into 2 groups by the method of random numbers. In the first group, the method of pregnancy termination with the Mifepristone 200mg tablet orally and laminar sticks, then after 12-24 hours the Misoprostol 200mcg tablets into the vagina; in the second group, the method of pregnancy termination with the Mifepristone 200mg tablet orally and laminar sticks, then after 12-24 hours the Misoprostol 400mcg tablets into the vagina. The analysis of the miscarriage outcomes, depending on the methods of medical pregnancy termination, taking into account the anamnesis, especially the course of miscarriage, post-abortion period and ultrasound examination data of pelvic organs. Results: the average time of fetus and placenta expulsion in the first group was 6 hours and 40 minutes, In the second group it equaled 7 hours and 45 minutes. Efficiency in group number 1 was 96.7%, in group number 2 it was 94.1%. The miscarriage was complicated by the incomplete abortion in 4 cases in the first group and in the second group in 2 cases. Control ultrasound examination of the pelvic organs showed an expansion of the uterine cavity from 8 mm to 37 mm, the average value was 15 mm on days 3 and 4 of the post-abortion period. Conclusion. The most effective and safest method of terminating a pregnancy is medical termination. The scheme of using Mifepristone 200mg tablets orally once, laminar sticks, after 12-24 hours, the 200mcg Misoprostol tablets into the vagina are the most ‘physiological’.