Background and Aims: Laryngoscopy and endotracheal intubation are associated with strong sympathetic responsein the form of tachycardia and hypertension. The aim of this study was to evaluate the efficacy of intravenous Dexmedetomidine in attenuation of haemodynamic response to laryngoscopy and endotracheal intubation. Materials and methods: In this prospective, randomized, double blinded study,A total of hundred patients of ASA grade I and II between 18 to 50 years of age scheduled for various elective surgical procedures under general anesthesiawere selected and randomized into two groups of fifty patients each. Group C received 10 ml of normal saline intravenously over 10 min, 10 minutes prior to induction. Group D received injection Dexmedetomidine 0.5µg/kg body weight diluted to 10 ml normal saline intravenously over 10 min, 10 minutes prior to induction. Baseline parameters like Heart rate [HR], Systolic blood pressure [SBP], Diastolic blood pressure [DBP] and Mean arterial pressure [MAP] were recorded in all patients before giving studydrug, 2 ,5 and 8 minutes after studydrug, just beforeinduction, immediately after induction, 1,3,4,10 minute after laryngoscopy andintubation