Introduction: Guillain–Barre syndrome (GBS) is one of the most frequent causes for acute flaccid limb weakness and also one of the most common causes of neuromuscular respiratory failure with an average incidence of 17%–30% patients requiring mechanical ventilation. This respiratory failure caused by GBS contributes to morbidity and mortality significantly, linked to even more worsening outcomes leading to poor long-term functional prognosis. Materials and Methods: This is a prospective observational study conducted for a year from August 2018 to September 2019 at a tertiary care hospital, where clinical-laboratory assessment and nerve conduction studies were performed and analysed among the 64 consecutive patients attended and hospitalized with Guillain-Barre syndrome in our hospital. Results: The present study happened from August 2018 to September 2019 among 64 GBS patients, out of which 38 were males and 26 females. Their ages ranged from 11 yrs. to 68 yrs., where the maximum number of patients i.e., 18 (28%) were between 21-30 years of age group. Discussion: In this study, 42 (65.6%) were, < 40 years and 22 (34.4%) were aged > 40 years. Sex ratio showed a slight male preponderance in most of the studies. [7, 8] Preceding events prior to the illness in present study is observed in thirty-three patients (52%) had preceding illness, most of previous studies shows antecedent event in >50% patients. Conclusion: Marked patterns of abnormalities in electrophysiological functions are observed in patients that are correlated with the period of mechanical ventilation. Autonomic dysfunctions are noticed among one third of the patients in this study, where the recovery rate is satisfactory.