Ayurveda the science of life and the system of traditional medicine defines the health and different diseases with its treatment in detailed. Before the narration of diseases and its treatment, Ayurveda Acharya defines the human body under the concept of Sharira. Sharira is made up of the Anga, Pratyanga, Indriya and Avyava. Ayurveda Acharya defines the formation of Ayurveda under Garbha Avakranti or Garbha Masanumasika Vikasa. The Vikasa means the development which takes place in sequential manner. According to modern embryological organ development; organogenesis takes place in first trimester. Trigeminal layers (Ectoderm, Mesoderm and Endoderm)arethe basis of the organogenesis, and hence the different organs get developed with the different proportion and component of the germ layers cells. After comparison of the Avayava Utpatti Siddhanta and trigeminal layer theory of modern embryological organogenesis one can find the resemblance in organ formation explained in Ayurveda as well as in modern embryology. Dosha, Dhatu, and Mala are the basis of Avayava Utpatti in Ayurveda and germ layers are the basis of organogenesis in embryology.