Emotional intelligence mediates the development of intrapersonal skills to identify determine interventions that promote it and improve differently able employees. Still, many supervisors feel that new differently able employee have inadequate communicative and competencies. The objective of this study is to examine the factors that affect emotional intelligence mediating effect of Intrapersonal Skills, among differently able employees of Public and Government sectors in Cuddalore District, Tamilnadu, India. The study was conducted by taking 243 differently able employees who are belonging to the Chennai. The random sampling method was used in this study and also the surveying method used to collect the data. The Intrapersonal Skills as evolved Emotional, Self-Awareness, Assertiveness, SelfRegard, Self-Actualization, Independence. The results suggest and improves differently able employee’s social relationship skills. In particular, differently able employees in Intrapersonal Skills with superiors and coworker in differently able employees of manufacturing industry