Background:Meibomian gland dysfunction (MGD) is a common ocular disorder, often underdiagnosed, and is a major contributory factor causing dry eye disease and ocular discomfort due to compromised quality of tears. A variety of physical measures, lubricants and antibiotics have been tried to alleviate the condition. Topical Azithromycin has been observed to provide relief in MGD. Interest has been generated in this drug due to its anti- inflammatory properties in addition to its antibiotic effect. Materials and Methods: The present study was undertaken to study the clinical efficacy of topical Azithromycin in MGD. 70 patients randomly detected with MGD were given Azithromycin 1% topically