Background: Different varieties of cements have been used in dentistry though many years to retain the restoration in a fixed position within the mouth. Cement solubility is considered to be a primary cause for the failure of cast restoration. The rate of luting cement dissolution is directly related to the degree of marginal opening. Larger the marginal gap, more the exposure of dental cement to oral environment and more rapid is the rate of cement dissolution Solubility contributes to loss of marginal integrity, surface properties and decreased aesthetics, resulting in restoration failure. Objective: To evaluate the solubility of various commercially available dental cements in artificial saliva at different pH and time. Material and methods: One forty-four samples of zinc polycarboxylate, zinc phosphate, glass ionomer cements and resin cement were prepared according to manufacturer’s instructions. After setting, they were weighed and each specimen were immersed in artificial saliva at three different pH (3.3, 6.7 and 12.3) for 24 hour, 48 hours and 7days. After specific time interval, samples were placed in desiccator and again weighed. Solubility of the cements were calculated by weight analyses. Results and Observation: The results of the study showed that the zinc phosphate cement has the highest solubility in acidic, basic as well as neutral environment followed by Zinc Polycarboxylate and glass ionomer cement. The least soluble cement is resin cement. Conclusion: Within the limit of this study, Zinc Phosphate showed highest solubility in acidic medium followed by basic medium and then in neutral environment. Resin cement is the least soluble. Further studies are warranted to better explore the results of this study.