Objective: To evaluate Anti-Arthritic activity of Ethanolic Extract of Tabernaemontana divaricata L. Flowers (EETF). Method: Natural based products with therapeutic properties has become an important field of interest in many countries. Animals were injected with 0.1 ml of CFA (Complete Freund's Adjuvant) intradermally. Ethanolic extract of Tabernaemontana divaricata L. Flowers (EETF) treated at different concentration i.e. 100 mg/kg, 150 mg/kg, 200 mg/kg orally. The rats body weight, paw volume using digital plethysmometer, stair case climbing, motility, hematological parameter, radiography, histopathology was measured. Result: The analysis of various arthritic assessment parameters used in this study revealed that Ethanolic Extract of Tabernaemontana divaricata L. Flowers (EETF) have considerable effect in preventing development of arthritis disease severity. Moreover, Ethanolic Extract of Tabernaemontana divaricata L. Flowers (EETF) revealed significant anti arthritis activity in both normal and CFA induced arthritis rats. Conclusion: Ethanolic Extract of Tabernaemontana divaricata L. Flowers (EETF) shows pharmacological rationale for the traditional use of the plant against inflammatory conditions like rheumatoid arthritis.