Abstract: Background: Addressing the needs of young adults undergoing orthodontic for faster treatment with unrealistic requirements has become challenge in modern era to orthodontists. So, to meet the treatment needs of the patients a combined multidisciplinary approach of orthodontists and oral surgeon is required. Various techniques are emerging in accelerated orthodontics field. Piezosurgery being a novel minimally invasive technique has shown to be a emerging trend with good results with the piezocision technique. Objectives: We aim to evaluate and compare the conventional corticotomy with piezo-guided corticotomy in accelerated osteogenic orthodontic treatment. Methods: This randomized comparative study has sample size of 24 subjects equally divided in two groups, i.e. conventional corticotomy group done with bur and piezo-guided corticotomy group. The time required for the surgical procedure, rate and amount of tooth movement and total treatment time required for completion of space closure was measured. Along with this, secondary parameters like gingival recession, periodontal pocket formation and dehiscence/ fenestration formation were also assessed. Results: Piezosurgery being minimally invasive requires more time for surgical procedure, however, it more efficiently moved tooth with reduced total treatment time when compared to conventional corticotomy. The piezosurgical group resulted in faster rate as well as amount of tooth movement than bur group. Although there was no statistically significant difference evident in complications associated with accelerated orthodontics tooth movement. Conclusion: A novel, minimally invasive approach for surgical orthodontics with better patient acceptance is equally effective in accelerating orthodontic tooth movement and definitely widen the scope of surgically accelerated orthodontic treatment with prognostically satisfactory clinical outcomes.