Introduction: The ill effects of tobacco on human health have been well demonstrated yet tobacco continues to find a very special place in the present day to day life probably because of the stimulant effects of nicotine.5, The present study was conducted to assess failure rate of dental implant in smokers and healthy subjects. Materials & methods: 54 smokers (group I) and equal number of healthy subjects (group II) who received dental implant in last 5 years of both genders were recruited. Amount of bone loss around the implant over 1mm of bone loss in the first year and over 0.3 mm bone loss every subsequent year were considered as failures. Results: Group I consisted of 68 patients (smokers) with 76 dental implants. Group II consisted of 54 patients (healthy subjects) with 78 implants. In group I, there were 16 and in group II, there were 3 dental implant failures. At first year, in group I, mean bone loss around implant was 1.21 mm and 0.5 mm in group II. Upto 5 years, in group I, mean bone loss around implant was 2.7 mm and 1.4 mm in group II. The difference was significant p< 0.05). Conclusion: Smokers had higher dental implant failure rates as compared to healthy subjects. Key words: Dental implant, Failure, Smoker