Background:Theriskfactorsforimplantareduetosurgicalprocedureandpatientcharacteristics. The present study was conducted to assess effect of diabetes and smokingonprognosis of dentalimplants. Materials & Methods: 120 patients who received dental implants in last 2 years weredivided into 4 groups of 30 each. Group I were smokers and non- diabetic, group II werediabetic and non- smokers, group III were smokers and diabetics and group IV werecontrols.Success rate of dental implants wereassessed. Results: There were 18 males and 12 females in group I, 14 males and 16 females in groupII, 13 males and 17 females in group III and 15 males and 15 females in group IV. Therewere 24 successful implants in group I, 23 in group II, 23 in group III and 28 in group IV.Thedifferencewas significant (P< 0.05). Conclusion:Successratewashighestamonghealthyascomparedtodiabeticsandsmokers.