Aims: To evaluate the effectiveness of pedicle screw fixation for thoraco-lumbar injuries. Methods: In this prospective study thirty-eight patients of thoraco-lumbar spine injuries treated with pedicle screw fixation with or without laminectomy were evaluated. In all patient’s posterior midline approaches were used for pedicle screw fixation. Pedicle screw inserted by free hand technique or by fluoroscopy visualization assistance. Functional outcome was assessed by Oswestry disability index (ODI). Results: Out of thirty-eight patients, ten patients were caused by road traffic accidents, twenty patients caused by fall from height, and three patients caused by slip on floor. Majority of cases operated within 5 days of trauma. Duration of hospital stay was 5 to 15 days.Out of 17 patients in which laminectomydone for neurological loss, 13 patients were completely recovered without residual neurological deficit. Incomplete recovery in two cases. No neurological improvement in two cases of complete paraplegia.No cases of dural tear andpost operative infection.