The innovative application of modern smartphone and wearable health applications and sensor technology (mHealth) has the ability to reduce health care expenses and in other respects enhance well-being. These apps are being developed in a number of areas, but there is a need for comprehensive research to investigate the possibilities and complexities of utilizing mobile devices to enhance health outcomes. Currently data for mHealth’s efficacy is scarce. While such innovations can be enticing and apparently innocuous, work is required to determine what, when, and for whom successful mHealth tools, applications, and systems are. This paper demonstrates mHealth Technologies in the following categories: assessment of interventions; assessment of evaluations; and reshaping the collection of proof utilizing mHealth. To describe an approach to the production of evidence in the mHealth domain that will ensure work is carried out on a robust methodological and theoretical basis. This paper draws together these principles to explain existing expectations of assessment, address potential prospects, and set an ambitious target for the developing area of mHealth science.