Suppositories are solid dosage forms intended to be inserted into body orifices where they melt at body temperature or dissolve in body fluid to exert local or systemic effects. Their action is determined by the drug's nature, concentration, vehicle, and absorption rate.Many reasons have been advanced for using the rectal route for drug administration, including avoiding gastrointestinal problems in patients, the unpleasant taste or odour of drugs, the first-pass effect, and the ease of use for children and unconscious patients.This study looks at how to make piroxicam suppositories in traditional and hollow forms for rectal administration to produce a higher and faster drug release by combining different bases.Piroxicam pure powder (Provizier Pharma, India), disodium hydrogen phosphate dihydrate (Na2HPo4.2H2O), gelatin and liquid paraffin, lactose powder, PEG 200, PEG 4000, and PEG 6000, ethyl oleate, glycerin, and potassium dihydrogen ortho-phosphate (KH2PO4), PEG 400, tween 80, and propylene glycol, the following two varieties of piroxicam suppositories were made:1- Piroxicam suppositories in their traditional form. 2-Suppositories with piroxicam powder or solution in a hollow kind. The difference between various groups was investigated using the variance (ANOVA) test. Using the SPSS18 window, the difference between the two groups was analyzed using the student's t-test. The minimum level of statistical significance was defined as a probability value (p0.05).In comparison to corresponding conventional suppositories (F1, F2, F4, and F5) and hollow suppositories loaded with Piroxicam in powder form (F6–F9) containing the same base, Piroxicam released faster with a higher percentage from hollow suppositories loaded with Piroxicam in solution form (F10–F13) in addition to their best physical properties.