Background: Liver is one of the important target organ for insulin and its counter regulatory hormones, such as glucagon. Chronic liver disease (CLD) is often associated with glucose intolerance and diabetes. Glucose intolerance and frank diabetes are seen in a lot number of patients with chronic liver disease. The number of CLD patients continues to increase in INDIA because of alcohol (ethanol) consumption and epidemics of obesity and non-alcoholic fatty liver diseases (NAFLD)