Background & objective: Stroke is a dreadful health hazard all over the world as well as in our country and one of the leading causes of mortality & morbidity. The relationship between serum C-reactive protein (CRP) level and post stroke outcome is not well studied especially in Iraq. We were interested to study this relationship in our country. Methods: In this finding was a cross-sectional study, done from April-November/ 2021 consisting of 80 Iraqi stroke patients whose are selected randomly from neurological ward in AL-Hussein teaching hospital. Patients (confirmed by CT scan or MRI). Serum CRP & Lipid profile was determined by standard Methods. Results: Mean serum CRP level was 8.71 mg/L that was higher than normal subjects. Correlation analysis between serums CRP level of stroke patients with post stroke outcome was found to be positively correlated (r = 0.452/p<0.01). Conclusion: The current study identified elevation of CRP in acute stroke and a high CRP is clearly associated with more severe stroke and high mortality. The further periodic advance and follow up studies should be needed to sort out the possibility that stroke patients may be at greater risk of subsequent cardiovascular complications.