Cenchrus ciliaris L. also called as “Dhaman grass”, which is a general starvation food employed during drought and deficiency of food in Rajasthan. Among the collected germplasm accessions, one among the Cenchrus setigerus accessions exhibited prostrate activities which would be of enormous use in the greening of degraded lands where with few plants whole area can be covered and used for grazing. Actual aim of this study was intended to find out the pharmacological activities of the extract of various parts (e.g. roots, stems, leaves, seeds) of Cenchrus Ciliaris and Cenchrus Setigerus and the following evaluations were carried out like-analgesic activity, anti inflammatory and diuretic activity on animal model. The actual goal of this research work was to carry out the pharmacological screening of ethyl acetate (EA) and glacial acetic acid (GAA) extracts of various parts (e.g. roots, stems, leaves, seeds) of Cenchrus Ciliaris and Cenchrus Setigerus. All the extracts of both the plants were found to be safe up to 2000 mg/kg body weight. Finally, 200 mg /kg b.w. and 400 mg /kg b.w. were selected for this study and acute toxicity study revealed the nontoxic nature for each selected plant extracts. From all the test compounds, GAA extracts of both the plants with a dose size of 400 mg/kg body weight were found to be potent in analgesic activity which is comparable to standard, but EA extracts having lower activity, compared to others. Drugs that reduce the total number of writhing upto in 30 minutes can be considered as an effective analgesic. Moreover, group IX (Treated with mixtures of GAA extracts of Cenchrus Ciliaris dissolved in DMSO) is exhibited fairly better activity compared to other extracts. In the same way GAA extracts with higher doses showed significant antiinflammatory activity. The group of II, IX & X was treated by Diclofenac sodium (10 mg/kg b.w.) and GAA extracts of Cenchrus Ciliaris and Cenchrus Setigerus (400 mg/kg body weight) showed maximum inhibition of edema after 5hrs, which was 83.72, 81.37 & 67.45% respectively. The furosemide (10 mg/ kg) and GAA extracts of both the selected plants at higher doses (400 mg/kg) showed potent natriuretic and saliuretic activity as compared to normal control.