The review presents data on cognitive deficits in schizophrenia. The peculiarity of the clinical course and outcomes of schizophrenia is manifested in impaired ability to plan and maintain targeted strategies, which is the main symptom of cognitive deficit. The data presented in the review on the effectiveness and clinical and social significance of the assessment of the quality of life and the choice of second generation antipsychotics is the main criterion for determining remission in patients with schizophrenia.