Online ISSN: 2515-8260

FORMULATION DEGIGN AND EVALUATION OF FAST DISSOLVING TABLET CONTAINING CARBAMAZEPINE NANOCRYSTALS FOR SOLUBILITY AND DISSOLUTION ENHANCEMENT USING SOLUPLUS

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R. S. Moon, D. R. Satwadhar, P. A. Kamble

Abstract

Major problem to the development of highly effective formulation is poor aqueous solubility which affects stability and bioavailability of drugs. Therapeutic effectiveness depends upon bioavailability and ultimately upon the solubility of drug. Therefore there is need of systematic formulation approach to make such poorly soluble drugs bioavailable. Attempt has been made in the present investigation to increase the solubility and dissolution of carbamazepine an antiepileptic class II drug. Nanocrystals of carbamazepin were prepared using graft copolymer soluplus by antisolvent precipitation technique. The prepared nanocrystals were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Differential scanning calorimetry (DSC), X-ray diffractometry (XRD), Scanning electron microscopy (SEM), Particle size and saturation solubility. The optimized batch of prepared carbamazepine nanocrystals (0.938 mg/ml) showed remarkable increase in the aqueous saturation solubility i.e., 4.48 folds as compared to pure carbamazepine (0.209 mg/ml). The optimized carbamazepine nanocrystals with highest solubility converted into fast dissolving tablet. The tablets were evaluated for different parameters and found to possess more dissolution as compared to pure drug. The rise in solubility and dissolution may be due to either increase in surface area due to nanocrystalization or micellization by soluplus.

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