The bioactive components of Dendrophthoe falcata (L.f) Ettingsh leaves have been evaluated using GCMS analysis. The phytochemicals were determined using Shimadzu GC-MS QP2010 ultra model apparatus. The GC-MS analysis report of D.falcata revealed the presence of 1,2-Benzenedicarboxilic acid, DIE, Hexadecanoic acid, methyl ester, n-Hexadecanoic acid, Glycidol stearate, Cis-10-Heptadecenoic acid, methyl ester, Heptadecanoic acid, methyl ester, Methyl 2-octylcyclopropene-1-heptanoate, Campesterol, 9-Octadecenoic acid, methyl ester, 9,12-Octadecadienoic acid (Z,Z)-, Pentadecanoic acid, 14-Methyl-, methyl ester, Cis-13,16- Docasadienoic acid, Octadecanoic acid, Ethyl 2-dibromomethyl-6-cyano-7-ethoxy-5 phenyl-1,8-n aphthyridine3-carboxylate, cis-10-Nonadecenoic acid, methyl ester, Ethyl 9,12,15-octadecatrienoate, Eicosanoic acid, methyl ester, (R)-(-)-14-Methyl-8-hexadecyn-1-ol, Docasonoic acid, methyl ester, Docosanoic acid, methyl ester, 9- Hexadecanoic acid in the leaves. These phytochemicals possess antimicrobial activity, anticarcinogenic properties, anti-inflammatory, lowering cholesterol, a reduction in atherosclerosis, a heart disease, and used anti-fungal activities etc. These properties indicate that D. falcata phytochemicals are the alternate natural source to be used in modern system of medicines.