Herbal medicine has its origins in ancient cultures. It involves the medicinal use of plants to treat disease and enhance general health and wellbeing. More recently, herbs and spices have been identified as sources of various phytochemicals, many of which possess powerful antioxidant activity. Antioxidant factors found in plants are based upon constituent nutrients with demonstrated radical-scavenging capacities as well as upon non-vitamin or mineral substances. The Liver care extract contains active components from various parts of Boerhavia diffusa L, Eclipta alba, Phyllanthus niruri, Tinospora cordifolia and Trikatu (Piper longum L. , Piper nigrum and Zingiber officinale ) supplied bt Auropharma, Puducherry, were investigated for its hepatoprotective effect on paracetamol (2g/kg/b.wt/p.o) induced acute liver damage in Wistar albino rats. Hepatoprotection activity was measured by diagnostic marker enzymes such as AST, ALT ALP, total bilirubin and direct bilirubin; tissue enzyme parameters such as GSH, SOD and CAT. The Liver care extract at the dose of (100 mg/kg/p.o) produced significant hepatoprotective effect in albino (Wistar) male rats and the effects of Liver care extract were comparable to that of standard drug Silymarin. These results suggest that Liver care extract exhibits a very significant hepatoprotective effect in albino (Wistar) male rats.